US 12,318,529 B2
Apparatus for extracorporeal treatment of blood
Dominique Pouchoulin, Tramoyes (FR)
Assigned to GAMBRO LUNDIA AB, Lund (SE)
Filed by GAMBRO LUNDIA AB, Lund (SE)
Filed on Jul. 23, 2020, as Appl. No. 16/936,659.
Application 16/936,659 is a continuation of application No. 13/876,357, granted, now 10,737,011, previously published as PCT/IB2011/002098, filed on Sep. 8, 2011.
Claims priority of application No. 10010805 (EP), filed on Sep. 27, 2010.
Prior Publication US 2020/0345922 A1, Nov. 5, 2020
Int. Cl. A61M 1/36 (2006.01); A61M 1/16 (2006.01); A61M 1/34 (2006.01)
CPC A61M 1/3663 (2013.01) [A61M 1/16 (2013.01); A61M 1/1601 (2014.02); A61M 1/1643 (2014.02); A61M 1/3434 (2014.02); A61M 1/3437 (2014.02); A61M 1/3441 (2013.01); A61M 1/3451 (2014.02); A61M 2205/3393 (2013.01); A61M 2205/505 (2013.01)] 13 Claims
OG exemplary drawing
 
1. An apparatus for extracorporeal treatment of blood comprising:
a filtration unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane;
a blood withdrawal line connected to an inlet of the primary chamber;
a blood return line connected to an outlet of the primary chamber, said blood withdrawal line and said blood return line being configured to be connected to a cardiovascular system of a patient;
a blood pump configured for controlling a flow of the blood through the blood withdrawal line;
an effluent fluid line connected to an outlet of the secondary chamber;
at least two fluid lines comprising:
a pre-blood pump infusion line connected to the blood withdrawal line in a region of the blood withdrawal line that is positioned upstream of the blood pump, and
at least one of (i) a pre-dilution fluid line connected to the blood withdrawal line, (ii) a post-dilution fluid line connected to the blood return line, and (iii) a dialysis fluid line connected to an inlet of the secondary chamber;
at least two pumps selected from (i) a pre-blood pump configured to pump through the pre-blood pump infusion line, (ii) a pre-dilution pump configured to pump through the pre-dilution fluid line, (iii) a post-dilution pump configured to pump through the post-dilution fluid line, and (iv) a dialysis fluid pump configured to pump through the dialysis fluid line connected to the inlet of the secondary chamber; and
a control unit configured to:
calculate or receive initial set values of two or more fluid flow rates selected from the group including a fluid flow rate (Qeff) through the effluent fluid line, a fluid flow rate (Qrep) through the pre-dilution fluid line or the post-dilution fluid line, a fluid flow rate (Qpbp) through the pre-blood pump infusion line, a fluid flow rate (Qdial) through the dialysis fluid line, and a fluid removal rate (Qpfr) from the patient,
receive at least a prescribed dose (Dset) or calculate said prescribed dose (Dset) as a target mean value of one or more flow rates to be delivered across an entire patient treatment,
execute a flow rate update procedure comprising calculating updated set values for one or more of said fluid flow rates based on said prescribed dose (Dset) in order to deliver the prescribed dose (Dset) via the pre-blood pump and/or at least one of (i) the pre-dilution pump, (ii) the post-dilution pump, and (iii) the dialysis fluid pump during a reference time interval, wherein the initial set value of the fluid flow rate (Qpbp) through the pre-blood pump infusion line is maintained at the initial set value of the fluid flow rate (Qpbp) when the updated set values are calculated, and
cause the at least two pumps to operate at the one or more of said fluid flow rates based on the updated set values based on said prescribed dose (Dset) in order to deliver the prescribed dose (Dset) via the pre-blood pump and/or at least one of (i) the pre-dilution pump, (ii) the post-dilution pump, and (iii) the dialysis fluid pump.