	US 12,317,914 B2
	Compositions and methods using one or more autophagy-inducing amino acids to potentiate musculoskeletal effect of one or more anabolic amino acids
Jerome Feige, Crissier (CH); Philipp Gut, Geneva (CH); Gabriele Civiletto, Lausanne (CH); and Claire Boutry, Villars Burquin (CH)
Assigned to Societe des Produits Nestle S.A., Vevey (CH)
Appl. No. 17/596,144
Filed by SOCIETE DES PRODUITS NESTLE S.A., Vevey (CH)
PCT Filed Jun. 4, 2020, PCT No. PCT/EP2020/065534 § 371(c)(1), (2) Date Dec. 3, 2021, PCT Pub. No. WO2020/245299, PCT Pub. Date Dec. 10, 2020.
Claims priority of provisional application 62/858,496, filed on Jun. 7, 2019.
Prior Publication US 2022/0295854 A1, Sep. 22, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A23L 33/175 (2016.01); A23L 33/18 (2016.01); A61K 9/14 (2006.01); A61K 31/198 (2006.01); A61K 38/01 (2006.01); A61P 3/02 (2006.01); A61P 21/00 (2006.01)

CPC A23L 33/175 (2016.08) [A23L 33/18 (2016.08); A61K 9/14 (2013.01); A61K 31/198 (2013.01); A61K 38/011 (2013.01); A61K 38/018 (2013.01); A61P 3/02 (2018.01); A61P 21/00 (2018.01)]

18 Claims

1. A method of potentiating a musculoskeletal effect of one or more anabolic amino acids selected from the group consisting of Leucine, Isoleucine, Arginine, Glutamine, Citrulline and mixtures thereof in an individual in need thereof, the method comprising administering to the individual a composition comprising the one or more anabolic amino acids, the composition further comprising one or more autophagy-inducing amino acids in a total amount effective for the composition to be neutral or positive regarding autophagy, the one or more autophagy-inducing amino acids comprising (i) Proline; and (ii) at least one additional amino acid selected from the group consisting of Glycine, Cysteine, Valine, Serine, N-Acetyl Cysteine (NAC), Methionine and mixtures thereof,

wherein the composition further comprises protein that provides at least a portion of the one or more anabolic amino acids and/or at least a portion of the one or more autophagy-inducing amino acids, and

wherein the protein has a formulation selected from the group consisting of (i) at least 50% of the protein has a molecular weight of 1-5 kDa, (ii) at least 50% of the protein has a molecular weight of 5-10 kDa and (iii) at least 50% of the protein has a molecular weight of 10-20 kDa.