US 11,996,277 B2
Method of gain calibration
Hamish Stewart, Bremen (DE); Johannes Petzoldt, Bremen (DE); Bernd Hagedorn, Bremen (DE); and Dmitry Grinfeld, Bremen (DE)
Assigned to Thermo Fisher Scientific (Bremen) GmbH, Bremen (DE)
Filed by Thermo Fisher Scientific (Bremen) GmbH, Bremen (DE)
Filed on Apr. 25, 2022, as Appl. No. 17/660,525.
Claims priority of application No. 2106941 (GB), filed on May 14, 2021.
Prior Publication US 2022/0367165 A1, Nov. 17, 2022
Int. Cl. H01J 49/00 (2006.01); H01J 49/02 (2006.01); H01J 49/40 (2006.01)
CPC H01J 49/0036 (2013.01) [H01J 49/025 (2013.01); H01J 49/406 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of gain calibration for an ion detector operating at a detector voltage, the method comprising steps of:
generating single ions;
determining a parameter of a first relationship between a detector output of an ion detector and a number of ions for a first detector voltage, by detecting single ions at the ion detector;
detecting an ion peak at the ion detector using the first detector voltage, to determine a number of ions in the ion peak, based on the parameter of the first relationship;
adjusting the detector voltage to reduce a ratio between the detector output and a noise level and thereby obtain a second detector voltage at which the detector output for the ion peak remains above the noise level;
determining a parameter of a second relationship between the detector output and the number of ions for the second detector voltage, based on the determined number of ions in the ion peak.