	US 11,995,558 B2
	Apparatus for high density information storage in molecular chains
Kirsty A. McFarland, Melrose, MA (US); Andrew P. Magyar, Arlington, MA (US); Ian Ward Frank, Arlington, MA (US); Kenneth T. Kotz, Newton, MA (US); Stacey Markovic, Boston, MA (US); Haiyao Huang, Cambridge, MA (US); Steven J. Byrnes, Watertown, MA (US); Gregg E. Favalora, Bedford, MA (US); Melissa M. Sprachman, Somerville, MA (US); Ryan A. Dubay, Ludlow, MA (US); Emma Vargo, Berkeley, CA (US); Peter Cavanagh, Stanford, CA (US); and Erin Rosenberger, Quincy, MA (US)
Assigned to THE CHARLES STARK DRAPER LABORATORY, INC., Cambridge, MA (US)
Filed by The Charles Stark Draper Laboratory, Inc., Cambridge, MA (US)
Filed on May 17, 2019, as Appl. No. 16/415,666.
Claims priority of provisional application 62/672,972, filed on May 17, 2018.
Prior Publication US 2019/0354871 A1, Nov. 21, 2019
Int. Cl. G06N 3/12 (2023.01); B01L 3/00 (2006.01); B81B 1/00 (2006.01); C12N 9/12 (2006.01); C12N 15/10 (2006.01); C12P 19/34 (2006.01); G06N 3/123 (2023.01); G11C 13/02 (2006.01)

CPC G06N 3/123 (2013.01) [B01L 3/5027 (2013.01); B01L 3/502761 (2013.01); B01L 3/50851 (2013.01); B01L 3/527 (2013.01); B81B 1/006 (2013.01); C12N 9/12 (2013.01); C12N 15/1006 (2013.01); C12N 15/1065 (2013.01); C12N 15/1068 (2013.01); C12P 19/34 (2013.01); G11C 13/02 (2013.01); B01J 2219/00495 (2013.01)]

24 Claims

1. A polymeric chain-synthesizing method, comprising:

providing a manifold system including an input manifold and an output manifold;

forming internal channels in the input manifold and the output manifold;

holding several tubes extending parallel to each other between the input manifold and the output manifold and coupled to the internal channels;

immobilizing seed molecules in the tubes; and

selectively delivering light to different locations of the tubes to mediate or control chemical reactions for synthesis of sequences from the seed molecules to thereby synthesize polymeric chains to encode digital data into the polymeric chains by the selective delivery of the light while the tubes are held between the input manifold and the output manifold; and

introducing different reagents required for synthesis of the polymeric chains by flowing the different reagents through the tubes via the manifold system;

wherein different seed molecules are used to enable random access of the different chains.