US 11,994,525 B2
Membrane protein analysis substrate, method of producing membrane protein analysis substrate, method of analyzing membrane protein and membrane protein analysis grid
Atsushi Shimada, Fukuoka (JP)
Assigned to KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, Fukuoka (JP)
Filed by KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, Fukuoka (JP)
Filed on Mar. 30, 2023, as Appl. No. 18/193,357.
Application 18/193,357 is a continuation of application No. PCT/JP2021/039829, filed on Oct. 28, 2021.
Claims priority of application No. 2020-180734 (JP), filed on Oct. 28, 2020.
Prior Publication US 2023/0258665 A1, Aug. 17, 2023
Int. Cl. G01N 33/92 (2006.01); G01N 33/487 (2006.01)
CPC G01N 33/92 (2013.01) [G01N 33/48721 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A membrane protein analysis substrate, comprising:
an electron microscope grid having a plurality of through-holes;
a lipid bilayer membrane that is provided to cover at least one of the plurality of through-holes; and
membrane proteins that are retained in a part planarly overlapping positions of the through-holes covered by the lipid bilayer membrane,
wherein the lipid bilayer membrane has a lipid monolayer, and
wherein the lipid monolayer is larger than the through-hole in a plan view, adheres to the electron microscope grid, and constitutes a part of the lipid bilayer membrane.