US 11,994,517 B2
Analytical assay reaction cartridge containing magnetic capture beads and methods of production and use thereof
Aaron Kauffmann, Elkhart, IN (US); and Jon Stradinger, Kalamazoo, MI (US)
Assigned to Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
Appl. No. 18/000,944
Filed by Siemens Healthcare Diagnostics Inc., Tarrytown, NY (US)
PCT Filed Jun. 16, 2021, PCT No. PCT/US2021/037599
§ 371(c)(1), (2) Date Dec. 7, 2022,
PCT Pub. No. WO2021/257682, PCT Pub. Date Dec. 23, 2021.
Claims priority of provisional application 63/040,867, filed on Jun. 18, 2020.
Prior Publication US 2023/0194513 A1, Jun. 22, 2023
Int. Cl. G01N 33/543 (2006.01); B01L 3/00 (2006.01); G01N 33/68 (2006.01)
CPC G01N 33/54326 (2013.01) [B01L 3/502761 (2013.01); G01N 33/54386 (2013.01); G01N 33/6872 (2013.01); B01L 2200/04 (2013.01); B01L 2200/0668 (2013.01); B01L 2200/16 (2013.01); B01L 2400/043 (2013.01); G01N 2333/4737 (2013.01)] 26 Claims
OG exemplary drawing
 
1. An analytical assay reaction assembly, comprising:
an analytical assay reaction cartridge having a housing that comprises a reaction chamber, an inlet for introducing a liquid test sample into the reaction chamber, and a sample read window formed through a portion of the reaction chamber, wherein the sample read window has a shape with an outer edge that surrounds the shape of the sample read window that extends through the portion of the reaction chamber;
at least one solid analytical reagent, wherein the solid analytical reagent comprises magnetic beads coated with at least one anti-human red blood cell antibody, and wherein the solid analytical reagent is soluble in a liquid reagent; and
a magnetic assembly comprising a permanent magnet; and
wherein at least one contact point of the magnetic assembly is disposed substantially adjacent to at least one contact point on the outer edge of the sample read window of the analytical assay reaction cartridge.