US 11,994,502 B2
Automated online chromatographic sample dilution and preparation system
Adrian G. Amador, Framingham, MA (US); Yuanqing Fang, Belmont, MA (US); David D. Ford, Cambridge, MA (US); Mikhail V. Goncharuk, West Roxbury, MA (US); and Grace Russell, Waltham, MA (US)
Assigned to Snapdragon Chemistry, Inc., Waltham, MA (US)
Filed by Snapdragon Chemistry, Inc., Waltham, MA (US)
Filed on Jun. 7, 2021, as Appl. No. 17/340,264.
Claims priority of provisional application 63/035,287, filed on Jun. 5, 2020.
Prior Publication US 2021/0382023 A1, Dec. 9, 2021
Int. Cl. G01N 30/30 (2006.01); G01N 30/02 (2006.01); G01N 30/32 (2006.01); G01N 30/84 (2006.01); G01N 30/88 (2006.01)
CPC G01N 30/88 (2013.01) [G01N 30/30 (2013.01); G01N 30/32 (2013.01); G01N 30/84 (2013.01); G01N 2030/027 (2013.01); G01N 2030/324 (2013.01); G01N 2030/8435 (2013.01); G01N 2030/8804 (2013.01); G01N 2030/8809 (2013.01)] 28 Claims
OG exemplary drawing
 
1. A computer-implemented method for analyzing a product stream of a chemical reaction, comprising:
withdrawing via a mechanical scoop from a reactor, a portion of the product stream of the chemical reaction, the portion of the product stream having a volume of less than about 200 μL and a total suspended solids content of at least about 25 mg/L;
mixing the portion of the product stream with a diluent to produce a sample;
transferring the sample to a liquid chromatography device; and
developing, via the liquid chromatography device, a measured chemical profile of the sample for process monitoring or real time decision-making.