CPC C12N 15/1006 (2013.01) | 20 Claims |
1. A particle comprising:
a porous, positively charged core comprising a blend of bis(triethoxysilyl)ethylene and bis(3-triethoxysilylpropyl) disulfide (BTSPD);
an oligonucleotide layer adsorbed to the positive charged core;
an interacting layer comprising polyvinylpyrrolidone (PVP) adsorbed to the oligonucleotide layer; and
an outermost layer of non-porous, hydrolyzed organosilicon disulfide, wherein a diameter of the particle is about 440 nm.
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