US 11,993,556 B1
Peptoid-based inhibitors of the protein arginine methyltransferase (PRMT) family
Bryan Knuckley, Jacksonville, FL (US); Corey P. Causey, Jacksonville, FL (US); and Fatima Khwaja Rehman, Jacksonville, FL (US)
Assigned to University of North Florida Board of Trustees, Jacksonville, FL (US)
Filed by Bryan Knuckley, Jacksonville, FL (US); Corey P. Causey, Jacksonville, FL (US); and Fatima Khwaja Rehman, Jacksonville, FL (US)
Filed on Nov. 16, 2021, as Appl. No. 17/527,475.
Claims priority of provisional application 63/114,813, filed on Nov. 17, 2020.
Int. Cl. C07C 259/06 (2006.01)
CPC C07C 259/06 (2013.01) 11 Claims
 
1. A method of inducing apoptosis in at least one cancer cell comprising:
administering a therapeutically effective amount of a peptide mimetic to the at least one cancer cell wherein the peptide mimetic is a peptoid-based inhibitor of protein arginine methyltransferase (PRMT) comprising Formula (II)

OG Complex Work Unit Chemistry
wherein R1 is at least one amine monomer;
wherein R2 is at least one amine monomer;
wherein X is a halogen; and
wherein n is an integer between 1 and 4.