US 11,992,576 B2
Embolic compositions and methods
Jeffrey Groom, Belmont, MA (US); Craig Wiltsey, Waltham, MA (US); Quynh Pham, Methuen, MA (US); Nikhita Mansukhani, Allston, MA (US); Courtney Guertin, Watertown, MA (US); Lee Core, Needham, MA (US); and Upma Sharma, Somerville, MA (US)
Assigned to Arsenal Medical, Inc., Watertown, MA (US)
Filed by Arsenal Medical, Inc., Watertown, MA (US)
Filed on Jun. 9, 2021, as Appl. No. 17/342,945.
Claims priority of provisional application 63/036,564, filed on Jun. 9, 2020.
Prior Publication US 2021/0379207 A1, Dec. 9, 2021
Int. Cl. A61K 47/02 (2006.01); A61K 47/34 (2017.01); A61K 49/04 (2006.01); A61L 24/00 (2006.01); A61L 24/02 (2006.01); A61L 24/04 (2006.01); A61L 24/06 (2006.01); C08L 83/04 (2006.01)
CPC A61L 24/06 (2013.01) [A61K 47/02 (2013.01); A61K 47/34 (2013.01); A61K 49/04 (2013.01); A61K 49/0409 (2013.01); A61L 24/0021 (2013.01); A61L 24/02 (2013.01); A61L 24/043 (2013.01); A61L 24/046 (2013.01); C08L 83/04 (2013.01); A61L 2400/06 (2013.01); A61L 2430/36 (2013.01)] 29 Claims
 
1. A kit for forming crosslinkable compositions for vascular embolization, said kit comprising:
(a) a first fluid composition comprising a first polysiloxane having two or more unsaturated groups and a first imaging agent,
(b) a second fluid composition that comprises a first hydride material having two or more hydride groups and a second imaging agent which is the same or different from the first imaging agent,
(c) a dry composition comprising a first silica filler and optionally a second silica filler which is the same or different from the first silica filler, and
wherein the first fluid composition, second fluid composition, and dry composition are stable, and when mixed, form a crosslinkable composition having the first and second imaging agents substantially evenly dispersed in the crosslinkable composition; and
wherein the crosslinkable composition cures into a solid when injected into a target vessel and occludes the target vessel.