US 11,992,560 B2
Electrospun fibers for a local release of an anti-inflammatory drug and a promyelinating drug
Laura Calza, Monterenzio (IT); Luciana Giardino, Monterenzio (IT); Maria Letizia Focarete, Bologna (IT); Chiara Gualandi, Molinella (IT); Maria-Laura Bolognesi, Bologna (IT); Nadia Passerini, Bologna (IT); Giampiero Pagliuca, Bologna (IT); Teresa Gazzotti, Bologna (IT); and Elisa Zironi, Sasso Marconi (IT)
Assigned to ALMA MATER STUDIORUM—UNIVERSITÀ DI BOLOGNA, Bologna (IT)
Appl. No. 17/251,601
Filed by ALMA MATER STUDIORUM—UNIVERSITÀ DI BOLOGNA, Bologna (IT)
PCT Filed Jun. 14, 2018, PCT No. PCT/IT2018/000084
§ 371(c)(1), (2) Date Dec. 11, 2020,
PCT Pub. No. WO2019/239436, PCT Pub. Date Dec. 19, 2019.
Prior Publication US 2021/0244677 A1, Aug. 12, 2021
Int. Cl. A61K 9/70 (2006.01); A61K 9/00 (2006.01); A61K 31/12 (2006.01); A61K 31/19 (2006.01); A61K 31/192 (2006.01); A61K 31/196 (2006.01); A61K 31/197 (2006.01); A61K 31/198 (2006.01); A61K 31/40 (2006.01); A61K 31/405 (2006.01); A61K 31/407 (2006.01); A61K 31/42 (2006.01); A61K 31/421 (2006.01); A61K 31/4418 (2006.01); A61K 31/5415 (2006.01); A61K 31/5575 (2006.01); A61K 31/603 (2006.01); A61K 31/704 (2006.01); A61P 25/28 (2006.01)
CPC A61K 9/70 (2013.01) [A61K 9/0024 (2013.01); A61K 31/12 (2013.01); A61K 31/19 (2013.01); A61K 31/192 (2013.01); A61K 31/196 (2013.01); A61K 31/197 (2013.01); A61K 31/198 (2013.01); A61K 31/40 (2013.01); A61K 31/405 (2013.01); A61K 31/407 (2013.01); A61K 31/42 (2013.01); A61K 31/421 (2013.01); A61K 31/4418 (2013.01); A61K 31/5415 (2013.01); A61K 31/5575 (2013.01); A61K 31/603 (2013.01); A61K 31/704 (2013.01); A61P 25/28 (2018.01)] 11 Claims
OG exemplary drawing
 
1. Electrospun polymeric fibers in the form of scaffold, wherein part or all of said fibers are loaded with the promyelinating agent 3,3,5-Triiodo-L-thyronine (T3) and another part or all of said fibers are loaded with an anti-inflammatory agent, for a local release of said promyelinating agent and said anti-inflammatory agent in a method of treating a spinal cord injury, wherein said electrospun polymeric fibers are suitable to be implanted directly on top of a lesion, wherein the local release of said promyelinating agent and said anti-inflammatory agent in a method of treating a spinal cord injury occurs over an estimated time of 8 to 14 days.