US 11,992,551 B2
Implants with controlled drug delivery features and methods of using same
David S. Haffner, Mission Viejo, CA (US)
Assigned to GLAUKOS CORPORATION, San Clemente, CA (US)
Filed by GLAUKOS CORPORATION, San Clemente, CA (US)
Filed on Mar. 26, 2021, as Appl. No. 17/214,471.
Application 17/214,471 is a continuation of application No. 15/926,930, filed on Mar. 20, 2018, granted, now 10,959,941.
Application 15/926,930 is a continuation of application No. 14/724,610, filed on May 28, 2015, abandoned.
Claims priority of provisional application 62/004,824, filed on May 29, 2014.
Prior Publication US 2021/0315806 A1, Oct. 14, 2021
Int. Cl. A61K 9/00 (2006.01); A61F 9/00 (2006.01); A61F 9/007 (2006.01); A61K 31/5575 (2006.01); A61K 47/02 (2006.01); A61K 47/32 (2006.01)
CPC A61K 9/0051 (2013.01) [A61F 9/0017 (2013.01); A61F 9/00781 (2013.01); A61K 31/5575 (2013.01); A61K 47/02 (2013.01); A61K 47/32 (2013.01); A61F 2250/0067 (2013.01); A61F 2250/0068 (2013.01)] 33 Claims
OG exemplary drawing
 
1. A drug delivery ocular implant comprising:
an outer shell having a proximal end and a distal end, the outer shell being shaped to define an interior chamber;
a drug positioned within the interior chamber;
a drug release element configured to release the drug from the interior chamber, the drug release element comprising:
a distal compression member having an annular shape with an opening extending therethrough;
a proximal compression member having an annular shape with an opening extending therethrough; and
a membrane compressed between the distal compression seal member and the proximal compression member, wherein the compressed membrane is deformed from its undeformed state; and
a retainer configured to retain the drug release element in place relative to the outer shell;
wherein the drug release element is configured such that the drug passes through the opening in the distal compression member, through the compressed membrane, through the opening in the proximal compression member, and out the proximal end of the outer shell.