	US 11,992,536 B2
	Dual-targeting compound and preparation method and application thereof
Xiaoyuan Chen, Shandong (CN); Pengfei Xu, Shandong (CN); Xiaoming Wu, Shandong (CN); Zhide Guo, Shandong (CN); Qingbao Yang, Shandong (CN); and Xuejun Wen, Shandong (CN)
Assigned to YANTAI LANNACHENG BIOTECHNOLOGY CO., LTD., Shandong (CN)
Appl. No. 18/546,989
Filed by YANTAI LANNACHENG BIOTECHNOLOGY CO., LTD., Shandong (CN)
PCT Filed Dec. 9, 2022, PCT No. PCT/CN2022/137823 § 371(c)(1), (2) Date Aug. 18, 2023, PCT Pub. No. WO2023/098920, PCT Pub. Date Jun. 8, 2023.
Claims priority of application No. 202211201081.2 (CN), filed on Sep. 29, 2022.
Prior Publication US 2024/0131205 A1, Apr. 25, 2024
Int. Cl. A61K 51/00 (2006.01); A61K 47/55 (2017.01); A61K 51/04 (2006.01); A61M 36/14 (2006.01)

CPC A61K 51/0497 (2013.01) [A61K 47/55 (2017.08)]

14 Claims

1. A dual-targeting compound, wherein the compound structurally contains ligand structures specifically binding to FAP and integrin α_vβ₃at the same time, and the compound has the following structure shown in Formula (I):