US 11,992,508 B2
Micronized eggshell membrane particles and the use thereof to promote the healing of wounds
Ralf Schmidt, Oslo (NO); Henri-Pierre Suso, Oslo (NO); and Enda Kenny, Kilkenny (IE)
Assigned to BIOVOTEC AS, Oslo (NO)
Appl. No. 15/522,441
Filed by BIOVOTEC AS, Oslo (NO)
PCT Filed Oct. 28, 2015, PCT No. PCT/EP2015/075041
§ 371(c)(1), (2) Date Apr. 27, 2017,
PCT Pub. No. WO2016/066718, PCT Pub. Date May 6, 2016.
Claims priority of application No. 1419183 (GB), filed on Oct. 28, 2014; application No. 1506504 (GB), filed on Apr. 16, 2015; and application No. 1511476 (GB), filed on Jun. 30, 2015.
Prior Publication US 2017/0319629 A1, Nov. 9, 2017
Int. Cl. A61K 35/57 (2015.01); A61K 9/14 (2006.01); A61L 15/40 (2006.01); A61L 15/60 (2006.01); A61L 26/00 (2006.01); A61L 27/36 (2006.01); A61L 31/00 (2006.01); A61L 31/08 (2006.01); A61P 17/02 (2006.01)
CPC A61K 35/57 (2013.01) [A61K 9/14 (2013.01); A61L 15/40 (2013.01); A61L 15/60 (2013.01); A61L 26/0023 (2013.01); A61L 26/0057 (2013.01); A61L 26/008 (2013.01); A61L 27/3604 (2013.01); A61L 31/005 (2013.01); A61L 31/08 (2013.01); A61P 17/02 (2018.01); A61L 2300/30 (2013.01); A61L 2300/404 (2013.01); A61L 2300/41 (2013.01); A61L 2300/412 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method of promoting the healing of a non-healing chronic wound, wherein the non-healing chronic wound healing,
(i) has not healed in 30 days after wound formation, and
(ii) is stalled in the inflammatory stage of wound healing,
wherein said method consists of applying directly to the surface or interior of the non-healing chronic wound a particle consisting of micronized egg shell membrane (ESM) having a mean particle diameter of equal to or less than 80 μm and being essentially insoluble in water at a neutral pH, and
wherein the application of the particle to the non-healing chronic wound causes the non-healing chronic wounds to progress through the healing stages.