US 11,992,472 B2
Compositions and methods for enhancing the efficacy of contraceptive microbicides
Wendell Guthrie, San Diego, CA (US)
Assigned to Evofem, Inc., San Diego, CA (US)
Filed by Evofem, Inc., San Diego, CA (US)
Filed on Aug. 29, 2022, as Appl. No. 17/823,020.
Application 17/823,020 is a continuation of application No. 16/738,868, filed on Jan. 9, 2020, granted, now 11,439,610.
Application 16/738,868 is a continuation of application No. 16/239,314, filed on Jan. 3, 2019, granted, now 10,568,855, issued on Feb. 25, 2020.
Application 16/239,314 is a continuation of application No. 15/410,632, filed on Jan. 19, 2017, abandoned.
Application 15/410,632 is a continuation of application No. 14/864,673, filed on Sep. 24, 2015, granted, now 9,566,232, issued on Feb. 14, 2017.
Application 14/864,673 is a continuation of application No. 14/410,841, abandoned, previously published as PCT/US2013/032510, filed on Mar. 15, 2013.
Claims priority of provisional application 61/659,368, filed on Jun. 13, 2012.
Prior Publication US 2023/0241013 A1, Aug. 3, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/19 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 31/675 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/36 (2006.01)
CPC A61K 31/19 (2013.01) [A61K 9/0034 (2013.01); A61K 9/06 (2013.01); A61K 31/675 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/36 (2013.01)] 18 Claims
 
1. A method for preventing pregnancy comprising intravaginally administering a composition to a subject in need thereof, wherein the composition comprises: a) a matrix-forming compound selected from the group consisting of: alginic acid, chitosan, gellan gum, and poloxamer; b) a bioadhesive compound that is the same or different from the matrix-forming compound; c) L-lactic acid; and d) an aqueous-based pharmaceutically acceptable carrier, wherein the composition has a nonmatrix state when not in contact with ejaculate, and a matrix state when in contact with ejaculate, and wherein the total lactic acid in the composition is not in a form of racemic mixture.