	US 11,992,471 B2
	Reelin/VEGF-C production/activation promoter and skin external composition using the same
Phil June Park, Yongin-si (KR); Hyunsoo Kim, Yongin-si (KR); and Hyoung June Kim, Yongin-si (KR)
Assigned to AMOREPACIFIC CORPORATION, Seoul (KR)
Filed by AMOREPACIFIC CORPORATION, Seoul (KR)
Filed on Nov. 28, 2022, as Appl. No. 18/059,332.
Claims priority of application No. 10-2021-0167441 (KR), filed on Nov. 29, 2021.
Prior Publication US 2023/0165816 A1, Jun. 1, 2023
Int. Cl. A61K 31/185 (2006.01); A61K 9/00 (2006.01); A61K 47/02 (2006.01); A61K 47/12 (2006.01); A61K 47/36 (2006.01); A61K 47/46 (2006.01); A61P 29/00 (2006.01)

CPC A61K 31/185 (2013.01) [A61K 9/0014 (2013.01); A61K 47/02 (2013.01); A61K 47/12 (2013.01); A61K 47/36 (2013.01); A61K 47/46 (2013.01); A61P 29/00 (2018.01)]

2 Claims

1. A method for improving swelling, lymphedema, skin wrinkles, or obesity by applying an effective amount of the reelin and/or VEGF-C production and/or activation promoter comprising a compound of the following Chemical Formula 1 to skin of a subject:

wherein, in Chemical Formula 1,

L¹is a substituted or unsubstituted C1 to C20 alkylene group or a substituted or unsubstituted C6 to C20 arylene group.