US 11,992,301 B2
Monitoring treatment of peripheral artery disease (PAD) using diffuse optical imaging
Andreas H. Hielscher, Brooklyn, NY (US); Christopher J. Fong, New York, NY (US); Jennifer Hoi, Belmont, CA (US); Hyun K. Kim, Cresskill, NJ (US); and Michael Khalil, Miami Lake, FL (US)
Assigned to The Trustees of Columbia University in the City of New York, New York, NY (US)
Filed by The Trustees of Columbia University in the City of New York, New York, NY (US)
Filed on Aug. 5, 2022, as Appl. No. 17/881,844.
Application 17/881,844 is a continuation of application No. 16/093,775, granted, now 11,439,312, previously published as PCT/US2017/029027, filed on Apr. 23, 2017.
Claims priority of provisional application 62/417,741, filed on Nov. 4, 2016.
Claims priority of provisional application 62/326,822, filed on Apr. 24, 2016.
Prior Publication US 2023/0031593 A1, Feb. 2, 2023
Int. Cl. A61B 5/00 (2006.01); A61B 5/02 (2006.01); A61B 5/021 (2006.01); A61B 5/022 (2006.01); A61B 5/0225 (2006.01); A61B 5/0245 (2006.01); A61B 5/026 (2006.01); A61B 5/1455 (2006.01)
CPC A61B 5/0261 (2013.01) [A61B 5/00 (2013.01); A61B 5/0073 (2013.01); A61B 5/0075 (2013.01); A61B 5/02 (2013.01); A61B 5/02007 (2013.01); A61B 5/021 (2013.01); A61B 5/022 (2013.01); A61B 5/02255 (2013.01); A61B 5/0245 (2013.01); A61B 5/1455 (2013.01); A61B 5/6828 (2013.01); A61B 5/6829 (2013.01); A61B 5/6831 (2013.01); A61B 5/6884 (2013.01); A61B 5/7425 (2013.01); A61B 2560/0437 (2013.01); A61B 2562/04 (2013.01)] 14 Claims
OG exemplary drawing
 
7. A method of monitoring treatment of peripheral artery disease, the method comprising:
(a) affixing a first plurality of light sources having different wavelengths and a first plurality of light detectors to a first position on a subject's limb, wherein the first position corresponds to a first angiosome of the limb;
(b) transmitting light from the first plurality of light sources into a first portion of the subject's limb, detecting light reflected from the first portion of the subject's limb using the first plurality of light detectors, and using diffuse optical imaging to determine a level of perfusion in the first angiosome based on the detected light reflected from the first portion;
(c) affixing a second plurality of light sources having different wavelengths and a second plurality of light detectors to a second position on a subject's limb, wherein the second position corresponds to a second angiosome of the limb; and
(d) transmitting light from the second plurality of light sources into a second portion of the subject's limb, detecting light reflected from the second portion of the subject's limb using the second plurality of light detectors, and using diffuse optical imaging to determine a level of perfusion in the second angiosome based on the detected light reflected from the second portion,
wherein the first plurality of light sources and the first plurality of light detectors remain affixed to the first position during steps (b) and (d), and
wherein the second plurality of light sources and the second plurality of light detectors remain affixed to the second position during steps (b) and (d).