US 12,315,712 B2
Method for tuning with unresolved peaks on quadrupole mass spectrometers
Johnathan W. Smith, Austin, TX (US)
Assigned to Thermo Finnigan LLC, San Jose, CA (US)
Filed by THERMO FINNIGAN LLC, San Jose, CA (US)
Filed on Apr. 16, 2024, as Appl. No. 18/636,732.
Application 18/636,732 is a continuation of application No. 17/578,371, filed on Jan. 18, 2022, granted, now 11,984,307.
Prior Publication US 2024/0347329 A1, Oct. 17, 2024
Int. Cl. H01J 49/42 (2006.01); H01J 49/00 (2006.01)
CPC H01J 49/0036 (2013.01) [H01J 49/0009 (2013.01); H01J 49/42 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A mass spectrometer support apparatus, comprising:
deconvolving logic to obtain a mass spectrum measured by a mass spectrometer and deconvolve the spectrum using an initial peak shape, the initial peak shape previously determined when tuning a mass spectrometer;
centroider logic to integrate the deconvolved spectrum and populate a sparse vector of peak locations,
peak recovery logic to obtain an updated peak shape, and
diagnostic logic to compare the updated peak shape to the initial peak shape and determine the mass spectrometer is in a suboptimal state when a deviation between the updated peak shape and the initial peak shape crosses a threshold.