	US 12,313,636 B2
	Serum metabolic biomarkers for detecting tuberculosis and tuberculosis detection kit
Pintong Huang, Hangzhou (CN); Yajing Liu, Hangzhou (CN); Yan Su, Hangzhou (CN); and Chao Zhang, Hangzhou (CN)
Assigned to Zhejiang SUKEAN Pharmaceutical Co., Ltd., Hangzhou (CN)
Filed by Zhejiang SUKEAN Pharmaceutical Co., Ltd., Hangzhou (CN)
Filed on Jul. 12, 2023, as Appl. No. 18/350,764.
Application 18/350,764 is a continuation of application No. PCT/CN2022/136421, filed on Dec. 5, 2022.
Claims priority of application No. 202210321998.X (CN), filed on Mar. 29, 2022.
Prior Publication US 2023/0358766 A1, Nov. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/68 (2006.01); G01N 33/53 (2006.01); G01N 33/569 (2006.01); G01N 33/92 (2006.01)

CPC G01N 33/6893 (2013.01) [G01N 33/5308 (2013.01); G01N 33/5695 (2013.01); G01N 33/92 (2013.01); G01N 2800/26 (2013.01)]

1 Claim

1. A composition serving as a biomarker panel for detecting tuberculosis, comprising detecting reagents and 17 serum metabolic, wherein the detecting reagents comprising an iron particle matrix, and the 17 serum metabolites consisting of D-Leucic acid, leucic acid, L-Cystine, MG (0:0/14:0/0:0), S-Lactoylglutathione, Octacosanoic acid, Cer (d18: 1/12:0), Raffinose, LysoPC (20:1(11Z)/0:0), LysoPC (22:4(7Z,10Z,13Z,16Z)/0:0), PC(18:1(9Z)e/2:0), Torvoside CE(16:1(9Z)), all-trans-Heptaprenyl diphosphate, PC (15:0/16:0), Nicotinamide Adenine Dinucleotide Phosphate (NADP), TG(20:0/20:0/20:1 (11Z)), the biomarker panel can be utilized for differential diagnosis of tuberculosis.