US 12,313,633 B2
Reagents and methods for elemental mass spectrometry of biological samples
Alexander V. Loboda, Thornhill (CA); Olga Ornatsky, Richmond Hill (CA); Vladimir Baranov, Richmond Hill (CA); Nikita Zabinyakov, North York (CA); Anastasia Mavropoulos, Daly City (CA); Daniel Majonis, North York (CA); Bedilu Allo, Whitby (CA); and Taunia Closson, Markham (CA)
Assigned to Standard BioTools Canada Inc., Markham (CA)
Filed by Standard BioTools Canada Inc., Markham (CA)
Filed on Apr. 24, 2024, as Appl. No. 18/644,592.
Application 18/644,592 is a continuation of application No. 17/050,716, granted, now 12,000,838, previously published as PCT/US2019/029443, filed on Apr. 26, 2019.
Claims priority of provisional application 62/728,761, filed on Sep. 8, 2018.
Claims priority of provisional application 62/728,594, filed on Sep. 7, 2018.
Claims priority of provisional application 62/663,828, filed on Apr. 27, 2018.
Prior Publication US 2024/0369567 A1, Nov. 7, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/68 (2006.01); C07K 1/13 (2006.01); G01N 1/28 (2006.01)
CPC G01N 33/6848 (2013.01) [C07K 1/13 (2013.01); G01N 1/28 (2013.01); G01N 2458/15 (2013.01); G01N 2560/00 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method for quantifying one or more analytes within a sample, the method comprising:
a. providing the sample, wherein the one or more analytes are immobilised to a mass cytometry sample carrier, wherein the sample has been labelled with one or more mass-tagged specific binding pairs comprising one or more labelling atoms, wherein the mass cytometer sample carrier is planar and comprises a polydopamine layer, and
b. performing mass cytometry on the sample to determine a level of the one or more labelling atoms, wherein the level of the one or more labelling atoms corresponds to the copy number of the one or more analytes to quantify the analytes.