US 12,313,607 B2
Operation of an injector of a sample separation device
Thomas Ortmann, Straubenhardt/Ottenhausen (DE); Martin Seifried, Ettlingen (DE); Sam Wouters, Karlsruhe/Baden-Wuerttemberg (DE); and Irina Spuling, Karlsruhe (DE)
Assigned to Agilent Technologies, Inc., Santa Clara, CA (US)
Filed by Agilent Technologies, Inc., Santa Clara, CA (US)
Filed on Feb. 1, 2024, as Appl. No. 18/430,447.
Application 18/430,447 is a continuation of application No. 17/730,553, filed on Apr. 27, 2022, granted, now 11,946,913.
Claims priority of application No. 102021110707.5 (DE), filed on Apr. 27, 2021.
Prior Publication US 2024/0201143 A1, Jun. 20, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 30/20 (2006.01); G01N 30/14 (2006.01); G01N 30/32 (2006.01); G01N 30/02 (2006.01)
CPC G01N 30/20 (2013.01) [G01N 30/14 (2013.01); G01N 30/32 (2013.01); G01N 2030/027 (2013.01); G01N 2030/326 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A separation device, comprising:
a separation path between a fluid drive and a sample separation unit, wherein the sample separation device is configured to inject a fluidic sample in an injector path into a mobile phase in the separation path driven by the fluid drive to the sample separation unit for chromatographically separating the fluidic sample; and
a control unit configured to control an operation comprising:
blocking the injector path or at least a partial path thereof;
generating an overpressure in the blocked injector path or the partial path thereof by a pressure source; and
subsequently fluidically coupling the injector path or the partial path thereof to a region of lower pressure than the overpressure to generate an expansion stroke for releasing unwanted components from the injector path.