US 12,313,556 B2
Optical interference diagnostic apparatus and methods of use
Matthew R. Nickel, Leduc (CA); and Hillary M. Sweet, Leduc (CA)
Assigned to PAVONIS DIAGNOSTICS INC., Edmonton (CA)
Appl. No. 17/285,819
Filed by PAVONIS DIAGNOSTICS INC., Edmonton (CA)
PCT Filed Dec. 16, 2020, PCT No. PCT/CA2020/051730
§ 371(c)(1), (2) Date Apr. 15, 2021,
PCT Pub. No. WO2021/119814, PCT Pub. Date Jun. 24, 2021.
Claims priority of provisional application 62/951,560, filed on Dec. 20, 2019.
Prior Publication US 2022/0128479 A1, Apr. 28, 2022
Int. Cl. G01N 21/78 (2006.01); A61B 5/00 (2006.01); C25D 11/02 (2006.01); C25D 11/08 (2006.01); C25D 11/10 (2006.01); C25D 11/22 (2006.01); G01N 21/45 (2006.01)
CPC G01N 21/78 (2013.01) [A61B 5/0059 (2013.01); C25D 11/022 (2013.01); C25D 11/08 (2013.01); C25D 11/10 (2013.01); C25D 11/22 (2013.01); G01N 21/45 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A thin film optical interference apparatus for detecting the presence of a target compound, the apparatus comprising:
a single layer of an anodizable metal, the layer having a first portion that is anodized to form a porous metal oxide and a second portion that is non-anodized underlying the first portion; wherein
the first portion of the layer comprises a first thickness and a first refractive index generating a first optical path length,
the second portion of the layer comprises a second thickness and a second refractive index generating a second optical path length;
wherein the second optical path length is different than the first optical path length providing a first interference colour, and
a non-anodized metal electrodeposited on the porous metal oxide providing an enhanced interference colour compared to the first interference colour; and
wherein upon binding of the target compound to the apparatus, a third thickness and a third refractive index generates a third optical path length, the third optical path length being different than the first and second optical path lengths, resulting in a detectable change in interference colour indicative of the presence of the target compound.