	US 12,312,588 B2
	Nucleolin-targeting aptamers and methods of using the same
Bruce A. Sullenger, Durham, NC (US); Michael Goldstein, Durham, NC (US); Elizabeth D. Pratico, Durham, NC (US); Michael Kastan, Durham, NC (US); and Bethany Gray, Durham, NC (US)
Assigned to Duke University, Durham, NC (US)
Filed by Duke University, Durham, NC (US)
Filed on Jun. 2, 2023, as Appl. No. 18/205,390.
Application 18/205,390 is a division of application No. 16/645,762, granted, now 11,713,464, previously published as PCT/US2018/050240, filed on Sep. 10, 2018.
Claims priority of provisional application 62/555,745, filed on Sep. 8, 2017.
Prior Publication US 2024/0150772 A1, May 9, 2024
Int. Cl. C12N 15/115 (2010.01); A61P 35/00 (2006.01); C12Q 1/68 (2018.01)

CPC C12N 15/115 (2013.01) [A61P 35/00 (2018.01); C12N 2310/16 (2013.01)]

19 Claims

1. An aptamer comprising

a polynucleotide having at least 80% sequence identity to any one of SEQ ID NOS: 1-12, 22-473, 475-479, 481, 483-484, 486, 490-502, or 504-515,

wherein the polynucleotide comprises an unmodified form or comprises a modified form comprising at least one nucleotide base modification.