US 12,312,316 B2
Compounds and methods for the targeted degradation of androgen receptor
Andrew P. Crew, Chester, CT (US); Hanqing Dong, Madison, CT (US); Xin Chen, Trumbull, CT (US); Yimin Qian, Plainsboro, NJ (US); and Lawrence B. Snyder, Killingworth, CT (US)
Assigned to Arvinas Operations, Inc., New Haven, CT (US)
Filed by Arvinas Operations, Inc., New Haven, CT (US)
Filed on Jul. 28, 2017, as Appl. No. 15/663,273.
Application 15/663,273 is a continuation in part of application No. 15/002,303, filed on Jan. 20, 2016, granted, now 11,352,351, issued on Jun. 7, 2022.
Claims priority of provisional application 62/105,210, filed on Jan. 20, 2015.
Prior Publication US 2017/0327469 A1, Nov. 16, 2017
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 233/86 (2006.01); A61K 31/277 (2006.01); A61K 31/4166 (2006.01); A61K 31/4184 (2006.01); A61K 31/4188 (2006.01); A61K 31/435 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); C07C 255/54 (2006.01); C07C 271/24 (2006.01); C07D 213/82 (2006.01); C07D 231/14 (2006.01); C07D 235/02 (2006.01); C07D 237/24 (2006.01); C07D 239/42 (2006.01); C07D 241/28 (2006.01); C07D 401/04 (2006.01); C07D 401/08 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 471/10 (2006.01); C07D 491/107 (2006.01)
CPC C07D 233/86 (2013.01) [A61K 31/277 (2013.01); A61K 31/4166 (2013.01); A61K 31/4184 (2013.01); A61K 31/4188 (2013.01); A61K 31/435 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 45/06 (2013.01); A61K 47/545 (2017.08); C07C 255/54 (2013.01); C07C 271/24 (2013.01); C07D 213/82 (2013.01); C07D 231/14 (2013.01); C07D 235/02 (2013.01); C07D 237/24 (2013.01); C07D 239/42 (2013.01); C07D 241/28 (2013.01); C07D 401/04 (2013.01); C07D 401/08 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/10 (2013.01); C07D 491/107 (2013.01); C07C 2601/04 (2017.05)] 1 Claim
 
1. A compound selected from the group consisting of

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
and a pharmaceutically acceptable salt thereof.