US 12,312,304 B2
Method for continuous synthesis of acylnaphthalene with acylation liquid
Xuefeng Mao, Beijing (CN); Heng Li, Beijing (CN); Fating Hu, Beijing (CN); Jinlong Zhong, Beijing (CN); Junfang Li, Beijing (CN); Tong Wang, Beijing (CN); and Xiaoran Zhang, Beijing (CN)
Assigned to CCTEG CHINA COAL RESEARCH INSTITUTE, Beijing (CN)
Filed by CCTEG CHINA COAL RESEARCH INSTITUTE, Beijing (CN)
Filed on Nov. 21, 2022, as Appl. No. 18/057,394.
Application 18/057,394 is a continuation of application No. PCT/CN2022/115478, filed on Aug. 29, 2022.
Claims priority of application No. 202111075055.5 (CN), filed on Sep. 14, 2021; application No. 202111093577.8 (CN), filed on Sep. 17, 2021; application No. 202111638857.2 (CN), filed on Dec. 29, 2021; application No. 202210095938.0 (CN), filed on Jan. 26, 2022; application No. 202210135569.3 (CN), filed on Feb. 14, 2022; and application No. 202210530956.7 (CN), filed on May 16, 2022.
Prior Publication US 2023/0095165 A1, Mar. 30, 2023
Int. Cl. C07C 45/46 (2006.01); C07C 45/84 (2006.01)
CPC C07C 45/46 (2013.01) [C07C 45/84 (2013.01)] 20 Claims
 
1. A method for continuous synthesis of acylnaphthalene, comprising:
mixing a raw solution containing 2-methylnaphthalene with an acylation liquid to obtain an acylation reaction liquid with a molar ratio of the 2-methylnaphthalene: the acylation agent: the Lewis catalyst of 1:1.3:1.5;
adding the acylation reaction liquid into a microchannel reactor and a plurality of kettle reactors connected in series to perform acylation reaction;
performing hydrolysis reaction on the acylation reaction liquid immediately after the acylation reaction liquid flows out of the plurality of kettle reactors, to obtain a mixed solution; and
subjecting the mixed solution to separation, rectification and crystallization, to obtain 2-methyl-6-propionylnaphthalene.