	US 12,311,034 B2
	Feedback enabled synthetic genes, target seed match cassettes, and their uses
Steven James Gray, Southlake, TX (US); and Sarah Sinnett, Farmers Branch, TX (US)
Assigned to The University of North Carolina at Chapel Hill, Chapel Hill, NC (US)
Appl. No. 17/271,432
Filed by THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, Chapel Hill, NC (US)
PCT Filed Aug. 29, 2019, PCT No. PCT/US2019/048776 § 371(c)(1), (2) Date Feb. 25, 2021, PCT Pub. No. WO2020/047234, PCT Pub. Date Mar. 5, 2020.
Claims priority of provisional application 62/861,044, filed on Jun. 13, 2019.
Claims priority of provisional application 62/725,126, filed on Aug. 30, 2018.
Prior Publication US 2021/0170051 A1, Jun. 10, 2021
Int. Cl. A61K 48/00 (2006.01); A61P 25/28 (2006.01); C07K 14/47 (2006.01)

CPC A61K 48/005 (2013.01) [A61P 25/28 (2018.01); C07K 14/4703 (2013.01)]

9 Claims

1. A synthetic gene comprising:

a polynucleotide comprising a coding region encoding MECP2 and one or more regulatory regions, wherein the one or more regulatory regions comprise the nucleotide sequence of SEQ ID NO:2.