US 12,311,033 B2
Lipid nanoparticle formulations and compositions
Priya Prakash Karmali, San Diego, CA (US); Steven Tanis, Carlsbad, CA (US); and Yanjie Bao, San Diego, CA (US)
Assigned to Capstan Therapeutics, Inc.
Filed by CAPSTAN THERAPEUTICS, INC., San Diego, CA (US)
Filed on May 31, 2024, as Appl. No. 18/731,223.
Claims priority of provisional application 63/505,424, filed on May 31, 2023.
Claims priority of provisional application 63/510,061, filed on Jun. 23, 2023.
Claims priority of provisional application 63/520,303, filed on Aug. 17, 2023.
Claims priority of provisional application 63/595,201, filed on Nov. 1, 2023.
Prior Publication US 2024/0398982 A1, Dec. 5, 2024
Int. Cl. A61K 39/395 (2006.01); A61K 9/51 (2006.01); A61K 38/17 (2006.01); A61K 38/46 (2006.01); A61K 47/60 (2017.01); A61K 47/68 (2017.01); A61K 47/69 (2017.01); A61K 48/00 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/88 (2006.01)
CPC A61K 48/0033 (2013.01) [A61K 9/5123 (2013.01); A61K 38/1774 (2013.01); A61K 38/465 (2013.01); A61K 47/60 (2017.08); A61K 47/6849 (2017.08); A61K 47/6889 (2017.08); A61K 47/6929 (2017.08); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/88 (2013.01); C12N 2310/20 (2017.05)] 30 Claims
OG exemplary drawing
 
1. A lipid nanoparticle (LNP) comprising a lipid composition comprising:
about 35 to about 65 mol % an ionizable cationic lipid of structure

OG Complex Work Unit Chemistry
wherein R is

OG Complex Work Unit Chemistry
about 0.5 to about 3 mol % PEG-lipid comprising functionalized PEG-lipid and non-functionalized PEG-lipid,
about 7 to about 13 mol % a phospholipid, and
about 27 to about 50 mol % a sterol.