US 12,310,934 B2
Methods of treatment of spontaneous preterm birth
Marina Sirota, Belmont, CA (US); Brian Le, San Jose, CA (US); Ronald Wong, San Carlos, CA (US); and David Stevenson, Stanford, CA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US); and THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Stanford, CA (US)
Appl. No. 17/440,178
Filed by The Regents of the University of California, Oakland, CA (US); and The Leland Stanford Junior University, Stanford, CA (US)
PCT Filed Mar. 20, 2020, PCT No. PCT/US2020/023865
§ 371(c)(1), (2) Date Sep. 16, 2021,
PCT Pub. No. WO2020/191297, PCT Pub. Date Sep. 24, 2020.
Claims priority of provisional application 62/975,196, filed on Feb. 11, 2020.
Claims priority of provisional application 62/821,408, filed on Mar. 20, 2019.
Prior Publication US 2022/0347135 A1, Nov. 3, 2022
Int. Cl. A61K 31/192 (2006.01); A61K 31/135 (2006.01); A61K 31/167 (2006.01); A61K 31/19 (2006.01); A61K 31/222 (2006.01); A61K 31/353 (2006.01); A61K 31/4035 (2006.01); A61K 31/43 (2006.01); A61K 31/438 (2006.01); A61K 31/4402 (2006.01); A61K 31/4439 (2006.01); A61K 31/546 (2006.01); A61K 31/573 (2006.01); A61P 15/06 (2006.01)
CPC A61K 31/192 (2013.01) [A61K 31/135 (2013.01); A61K 31/167 (2013.01); A61K 31/19 (2013.01); A61K 31/222 (2013.01); A61K 31/353 (2013.01); A61K 31/4035 (2013.01); A61K 31/43 (2013.01); A61K 31/438 (2013.01); A61K 31/4402 (2013.01); A61K 31/4439 (2013.01); A61K 31/546 (2013.01); A61K 31/573 (2013.01); A61P 15/06 (2018.01)] 12 Claims
 
1. A method of treating spontaneous preterm birth in a subject in need of treatment therefor by the administration to the subject of a therapeutic composition comprising a therapeutically effective amount of one or more agents that partially reverse the gene expression profile associated with spontaneous preterm birth.