US 12,310,830 B2
Biocompatible membrane composite
Timothy M. Bruhn, Newark, DE (US); Kevin D'Amour, San Diego, CA (US); Christopher Folk, San Diego, CA (US); Craig McGreevy, San Diego, CA (US); Laura Martinson, San Diego, CA (US); Scott A. Ritrovato, Newark, DE (US); Greg Rusch, Newark, DE (US); Michael Scott, San Diego, CA (US); Lauren R. Zambotti, Newark, DE (US); Qiang (John) Zhang, San Diego, CA (US); and Joseph Kakkassery, San Diego, CA (US)
Assigned to W. L. Gore & Associates, Inc., Newark, DE (US); and ViaCyte, Inc., San Diego, CA (US)
Appl. No. 17/595,906
Filed by W. L. Gore & Associates, Inc., Newark, DE (US); and ViaCyte, Inc., San Diego, CA (US)
PCT Filed May 30, 2020, PCT No. PCT/US2020/035449
§ 371(c)(1), (2) Date Nov. 29, 2021,
PCT Pub. No. WO2020/243665, PCT Pub. Date Dec. 3, 2020.
Claims priority of provisional application 62/897,636, filed on Sep. 9, 2019.
Claims priority of provisional application 62/855,540, filed on May 31, 2019.
Prior Publication US 2022/0370184 A1, Nov. 24, 2022
Int. Cl. A61L 27/56 (2006.01); A61F 2/00 (2006.01); A61F 2/02 (2006.01); A61L 27/34 (2006.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01)
CPC A61F 2/0077 (2013.01) [A61F 2/022 (2013.01); A61L 27/34 (2013.01); A61L 27/3804 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61F 2002/0086 (2013.01); A61F 2210/0076 (2013.01)] 28 Claims
OG exemplary drawing
 
1. A biocompatible membrane composite comprising:
a first layer having pores with a maximum pore size (MPS) less than about 1 micron, wherein the first layer has a first thickness less than 10 microns, and wherein the first layer is cell impermeable; and
a second layer having solid features, wherein the second layer has a second thickness less than 200 microns, and wherein the second layer allows cellular ingrowth,
wherein a majority of the solid features has a solid feature spacing less than about 50 microns,
wherein the solid features each comprise a representative minor axis, a representative major axis, and a solid feature depth, and
wherein a majority of at least two of the representative minor axis, the representative major axis, and the solid feature depth are greater than about 5 microns.