| CPC A61B 5/14551 (2013.01) | 20 Claims |

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1. A method comprising:
at a device in communication with an optical sensor including a plurality of light detectors and a plurality of light emitters:
emitting light from the plurality of light emitters;
detecting light at the plurality of light detectors;
estimating a multi-dimensional representation of physiological characteristics in tissue using physiological characteristics computed from measurements of a plurality of channels of the optical sensor, each of the plurality of channels corresponding to at least one of the plurality of light emitters and at least one of the plurality of light detectors;
processing the multi-dimensional representation;
in accordance with a determination that the multi-dimensional representation includes a region that meets one or more criteria indicative of a spatially localized measurement inconsistency:
computing an estimated physiological characteristic from the multi-dimensional representation excluding the region.
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