US 12,310,724 B2
Cloud-based portable system for non-invasive real-time blood glucose measurement
Hari Chauhan, Revere, MA (US); J. Brian Harrington, Revere, MA (US); Teoman Emre Ustun, Lexington, MA (US); and Alexander Gray, Andover, MA (US)
Assigned to ANALOG DEVICES, INC., Wilmington, MA (US)
Filed by Analog Devices, Inc., Wilmington, MA (US)
Filed on Jun. 14, 2021, as Appl. No. 17/347,163.
Application 17/347,163 is a continuation of application No. PCT/US2019/064200, filed on Dec. 3, 2019.
Claims priority of provisional application 62/781,491, filed on Dec. 18, 2018.
Prior Publication US 2021/0307660 A1, Oct. 7, 2021
Int. Cl. A61B 5/1455 (2006.01); A61B 5/00 (2006.01); A61B 5/08 (2006.01); A61B 5/097 (2006.01); A61B 5/145 (2006.01)
CPC A61B 5/14532 (2013.01) [A61B 5/0004 (2013.01); A61B 5/0075 (2013.01); A61B 5/082 (2013.01); A61B 5/097 (2013.01); A61B 5/1455 (2013.01); A61B 2562/0271 (2013.01)] 4 Claims
OG exemplary drawing
 
1. A method for performing a non-invasive blood glucose level measurement, comprising:
translating raw optical measurements (“IT”) to calibrated optical transmission measurements (“A”) based on operating conditions of a light source device external to a body of a subject, with a ratio of the raw optical measurements and the operating conditions defining an internal transmittance, the operating conditions comprising radiant power (“Io”) of optical radiation emitted by the light source device;
preprocessing the calibrated optical transmission measurements;
providing the preprocessed calibrated optical transmission measurements to at least one chemometric model to obtain respective estimates of a concentration of acetone in a breath of the subject;
determining, using a lookup table, a defined internal transmittance value corresponding to the internal transmittance measured at a first wavelength;
determining, using the lookup table and the defined internal transmittance value, a defined concentration of acetone;
selecting, from the respective estimates, a particular estimate of the concentration of acetone in the breath of the subject that is closest to the defined concentration of acetone;
reporting an average of the defined concentration of acetone and the particular estimate as a measured concentration of the acetone in the breath of the subject, with the measured concentration of the acetone in the breath representing a level of blood glucose in the subject.