US 12,310,719 B2
Encapsulation device systems with oxygen sensors with or without exogenous oxygen delivery
Klearchos K. Papas, Tucson, AZ (US)
Assigned to ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, Tucson, AZ (US)
Filed by Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US)
Filed on Jul. 24, 2023, as Appl. No. 18/225,504.
Application 18/225,504 is a continuation of application No. 16/347,338, granted, now 11,723,558, previously published as PCT/US2017/060036, filed on Nov. 3, 2017.
Claims priority of provisional application 62/417,005, filed on Nov. 3, 2016.
Prior Publication US 2023/0414134 A1, Dec. 28, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); A61F 2/02 (2006.01)
CPC A61B 5/14503 (2013.01) [A61B 5/14532 (2013.01); A61B 5/14539 (2013.01); A61B 5/14542 (2013.01); A61B 5/14546 (2013.01); A61B 5/4836 (2013.01); A61B 5/686 (2013.01); A61F 2/022 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An implantable encapsulation device for housing cells, the device comprising:
a lumen for receiving and housing cells;
a vascularization membrane at least partially surrounding the lumen, and wherein the vascularization membrane is permeable to cells and comprises pores of less than 10 micrometers;
an immuno-isolation membrane provided adjacent the vascularization membrane and wherein the immuno-isolation membrane comprises smaller pores than the vascularization membrane;
an oxygen delivery system and a gas channel operable to deliver gas to the device;
a sensor provided in the device; and
wherein the sensor is operable to determine at least one of an oxygen level and an oxygen consumption rate.