US 11,990,241 B2
Apparatus for collagen evaluation and prognostic prediction of colorectal cancer and storage medium
Jun Yan, Shenzhen (CN); Shumin Dong, Shenzhen (CN); Botao Yan, Shenzhen (CN); Weisheng Chen, Shenzhen (CN); Xiaoyu Dong, Shenzhen (CN); Xiumin Liu, Shenzhen (CN); Shuhan Zhao, Shenzhen (CN); Jiaxin Cheng, Shenzhen (CN); Yanfeng Dong, Shenzhen (CN); Wei Jiang, Shenzhen (CN); Dexin Chen, Shenzhen (CN); and Guoxin Li, Shenzhen (CN)
Assigned to SHENZHEN PEOPLE'S HOSPITAL, Shenzhen (CN)
Appl. No. 18/286,475
Filed by SHENZHEN PEOPLE'S HOSPITAL, Shenzhen (CN)
PCT Filed Nov. 15, 2022, PCT No. PCT/CN2022/131939
§ 371(c)(1), (2) Date Oct. 11, 2023,
PCT Pub. No. WO2023/168981, PCT Pub. Date Sep. 14, 2023.
Claims priority of application No. 202210218325.1 (CN), filed on Mar. 8, 2022.
Prior Publication US 2024/0096491 A1, Mar. 21, 2024
Int. Cl. G06T 7/00 (2017.01); G06V 10/25 (2022.01); G06V 10/44 (2022.01); G16H 50/20 (2018.01)
CPC G16H 50/20 (2018.01) [G06T 7/0012 (2013.01); G06V 10/25 (2022.01); G06V 10/44 (2022.01); G06T 2207/30028 (2013.01); G06T 2207/30096 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A non-transitory computer readable storage medium storing a computer program, wherein the computer program comprises program instructions that, when executed by a processor, cause the processor to perform following steps:
acquiring a multi-photon imaging image of a target imaging region in a histopathological section, and performing image processing on the multi-photon imaging image to partition the multi-photon imaging image into a center of tumor (CT) region, an invasive margin (IM) region and a normal tissue (N) region;
extracting a value of each collagen feature parameter in each region, and calculating scoring parameters according to the value of each collagen feature parameter, wherein the scoring parameters comprise a mean of each collagen feature parameter in each region, an inter-region difference value and a variation value, wherein the inter-region difference value is a difference between means of each collagen feature parameter for any two regions, and the variation value is a ratio of two inter-region difference values; and the mean of each collagen feature parameter is an average value of a plurality of values of the collagen feature parameter corresponding to a plurality of subregions in a same region of three partitioned regions from the multi-photon imaging image; and
selecting the scoring parameters corresponding to target collagen features for collagen feature score calculation, thereby obtaining a collagen feature score of the histopathological section.