US 11,990,211 B2
Sample tracking via sample tracking chains, systems and methods
Nicholas James Witchey, Laguna Hills, CA (US); and Patrick Soon-Shiong, Los Angeles, CA (US)
Assigned to Nant Holdings IP, LLC, Culver City, CA (US)
Filed by Nant Holdings IP, LLC, Culver City, CA (US)
Filed on Feb. 9, 2021, as Appl. No. 17/171,584.
Application 17/171,584 is a continuation of application No. 15/708,837, filed on Sep. 19, 2017, granted, now 10,923,215.
Claims priority of provisional application 62/396,986, filed on Sep. 20, 2016.
Prior Publication US 2021/0166792 A1, Jun. 3, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. G16H 10/40 (2018.01); G06Q 10/0633 (2023.01); G16H 10/60 (2018.01); G16H 40/40 (2018.01); G06F 16/903 (2019.01)
CPC G16H 10/40 (2018.01) [G06Q 10/0633 (2013.01); G16H 10/60 (2018.01); G06F 16/90335 (2019.01)] 19 Claims
OG exemplary drawing
 
1. A digital histopathology sample tracking system, comprising:
a digitized image of a tissue sample stored in a first non-transitory computer readable memory, the tissue sample characterized by intrinsic properties derivable from the digitized image;
a sample tracking chain stored in a second non-transitory computer readable memory, the sample tracking chain including the intrinsic properties of the tissue sample; and
at least one processor coupled to the first and second memories, and configured to:
obtain the digitized image via scanning the tissue sample with a digital camera;
execute an implementation of at least one image processing algorithm on the digitized image to obtain a set of image descriptors;
classify a tumor cell type region of the digitized image based on the set of image descriptors;
generate intrinsic properties of the tumor cell type region based at least in part on the set of image descriptors;
extract at least one portion of the digitized image associated with the classified tumor cell type region;
store the at least one portion of the digitized image associated with the classified tumor cell type region, and the intrinsic properties associated with the at least one portion of the digitized image, in the sample tracking chain, wherein the at least one portion of the digitized image is indexed in and retrievable from the sample tracking chain via the intrinsic properties associated with the at least one portion of the digitized image; and
enable validation of a target biological sample by comparing intrinsic properties of the target biological sample to intrinsic properties stored in the sample tracking chain.