US 11,989,619 B2
Modifying messages stored in mixtures of molecules using thin-layer chromatography
George M. Whitesides, Newton, MA (US); Albert Siangyoong Wong, Enschede (NL); Michael Johannes Fink, Cambridge, MA (US); Khaled Abdelazim Mohamed, Cambridge, MA (US); Alexei S. Ten, Evanston, IL (US); and Milan M. Mrksich, Hinsdale, IL (US)
Assigned to President and Fellows of Harvard College, Cambridge, MA (US); and Northwestern University, Evanston, IL (US)
Filed by President and Fellows of Harvard College, Cambridge, MA (US); and Northwestern University, Evanston, IL (US)
Filed on Feb. 25, 2022, as Appl. No. 17/681,155.
Application 17/681,155 is a continuation of application No. PCT/US2020/048190, filed on Aug. 27, 2020.
Claims priority of provisional application 62/892,171, filed on Aug. 27, 2019.
Prior Publication US 2022/0180083 A1, Jun. 9, 2022
Int. Cl. G06K 7/10 (2006.01); B01J 19/00 (2006.01); G01N 30/90 (2006.01); G06K 7/14 (2006.01); G06K 19/06 (2006.01)
CPC G06K 7/1434 (2013.01) [B01J 19/0046 (2013.01); G01N 30/90 (2013.01); G06K 19/06037 (2013.01); B01J 2219/00605 (2013.01); B01J 2219/00659 (2013.01); B01J 2219/00695 (2013.01); B01J 2219/00725 (2013.01)] 2 Claims
OG exemplary drawing
 
1. A method of writing data to a machine-readable medium, the method comprising:
receiving a numerical value comprising a set of digit/position pairs, the set comprising at least a first subset of digit/position pairs, and a second subset of digit/position pairs;
receiving an association between at least the first and the second subsets of digit/position pairs and the set of digit/position pairs;
receiving a one-to-one association between at least the first subset of digit/position pairs and a first subset of molecules, and the second subset of digit/position pairs and a second subset of molecules, the first and the second subsets of molecules each selected from a set of unambiguously identifiable molecules, wherein each molecule in the first subset is identifiable by a first physical property, and each molecule in the second subset is identifiable by a second physical property, different from the first physical property;
determining a collection of molecules corresponding to the numerical value, wherein determining the collection comprises:
determining at least a first subcollection of molecules corresponding to the first subset of digit/position pairs, and a second subcollection of molecules corresponding the second subset of digit/position pairs, and
including at least the first and the second subcollections into the collection of molecules; and
physically associating the molecules of the collection with a substrate of the machine-readable medium at an addressable location thereon.