US 11,988,647 B2
Combination mixer arrangement for noise reduction in liquid chromatography
Fabrice Gritti, Franklin, MA (US)
Assigned to Waters Technologies Corporation, Milford, MA (US)
Filed by Waters Technologies Corporation, Milford, MA (US)
Filed on Jun. 25, 2021, as Appl. No. 17/358,391.
Claims priority of provisional application 63/081,524, filed on Sep. 22, 2020.
Claims priority of provisional application 63/048,684, filed on Jul. 7, 2020.
Prior Publication US 2022/0011276 A1, Jan. 13, 2022
Int. Cl. G01N 30/06 (2006.01); G01N 30/16 (2006.01); G01N 30/02 (2006.01)
CPC G01N 30/06 (2013.01) [G01N 30/16 (2013.01); G01N 2030/027 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A mixer arrangement for use in a chromatography system comprising:
a first frequency targeting mixer including a first flow channel coupled between an inlet and an outlet and a second flow channel coupled between the inlet and the outlet, the second flow channel including a volume offset region configured to delay fluid propagation through the second flow channel, wherein the volume offset region is configured to reduce or eliminate fluidic compositional oscillations in a compositional solvent stream that depart from a desired composition at a first target frequency; and
a residual noise targeting mixer fluidically connected in series to the frequency targeting mixer, the residual noise targeting mixer configured to dampen aperiodic baseline noise in the compositional solvent stream.