US 11,988,636 B2
Method for particle analysis and method for particle production
Makoto Kawano, Ikeda (JP); Ayako Tatematsu, Tokyo (JP); and Ryosuke Abe, Tokyo (JP)
Assigned to KAWANO Lab. Inc., Osaka (JP); and TableMark Co., Ltd., Tokyo (JP)
Filed by KAWANO Lab. Inc., Osaka (JP); and TableMark Co., Ltd., Tokyo (JP)
Filed on Apr. 24, 2020, as Appl. No. 16/858,432.
Prior Publication US 2020/0340947 A1, Oct. 29, 2020
Int. Cl. G01N 27/76 (2006.01); A23L 27/00 (2016.01); A23P 10/30 (2016.01); B01J 13/02 (2006.01); G01N 15/00 (2006.01); G01N 15/10 (2006.01); G01N 15/1031 (2024.01); B01J 13/04 (2006.01)
CPC G01N 27/76 (2013.01) [A23L 27/72 (2016.08); A23P 10/30 (2016.08); G01N 15/1031 (2013.01); B01J 13/02 (2013.01); B01J 13/04 (2013.01); G01N 2015/0038 (2013.01); G01N 2015/1027 (2024.01)] 6 Claims
OG exemplary drawing
 
1. A method for particle analysis, the method comprising:
a first observation step of observing first particles subjected to magnetophoresis;
a first migration velocity measurement step of measuring a magnetophoretic velocity of the first particles based on an observation result in the first observation step;
a first magnetic susceptibility measurement step of measuring a volume magnetic susceptibility of each of the first particles based on a result of measurement in the first migration velocity measurement step;
an encapsulation treatment step of performing an encapsulation treatment so that the first particles encapsulate an encapsulation target component smaller than the first particles;
a second observation step of observing second particles that are the first particles after the encapsulation treatment subjected to magnetophoresis;
a second migration velocity measurement step of measuring a magnetophoretic velocity of the second particles based on an observation result in the second observation step;
a second magnetic susceptibility measurement step of measuring a volume magnetic susceptibility of each of the second particles based on a result of measurement in the second migration velocity measurement step;
a step of analyzing whether or not the encapsulation target component is encapsulated in the second particles based on a result of measurement in the first magnetic susceptibility measurement step and a result of measurement in the second magnetic susceptibility measurement step;
a first zeta potential measurement step of measuring a zeta potential of the first particles;
a second zeta potential measurement step of measuring a zeta potential of the second particles; and
a step of analyzing whether or not the encapsulation target component is encapsulated in the second particles based on a result of measurement in the first zeta potential measurement step and a result of measurement in the second zeta potential measurement step.