US 11,988,585 B2
Refractive index matching formulations
Adam York, Eugene, OR (US); Eric Welch, Eugene, OR (US); and Daniel Cash, Eugene, OR (US)
Assigned to LIFE TECHNOLOGIES CORPORATION, Carlsbad, CA (US)
Appl. No. 16/641,193
Filed by LIFE TECHNOLOGIES CORPORATION, Carlsbad, CA (US)
PCT Filed Sep. 11, 2018, PCT No. PCT/US2018/050392
§ 371(c)(1), (2) Date Feb. 21, 2020,
PCT Pub. No. WO2019/051466, PCT Pub. Date Mar. 14, 2019.
Claims priority of provisional application 62/557,028, filed on Sep. 11, 2017.
Prior Publication US 2021/0033502 A1, Feb. 4, 2021
Int. Cl. G01N 1/36 (2006.01); C08K 3/30 (2006.01); C08K 5/09 (2006.01); G01N 1/30 (2006.01); G02B 21/34 (2006.01)
CPC G01N 1/36 (2013.01) [C08K 3/30 (2013.01); C08K 5/09 (2013.01); G01N 1/30 (2013.01); G01N 2001/364 (2013.01); G02B 21/34 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A refractive index matching (RIM) solution, comprising:
a) a water-soluble polymer, wherein the polymer has a molar refraction (RLL) to molar volume (Vm) ratio of 0.27 to 0.34, wherein the water-soluble polymer is uncharged, wherein the uncharged, water-soluble polymer comprises a monomer residue of N—R acrylamide or N—R methacrylamide, wherein R is methyl, ethyl, propyl, isopropyl or N,N-dimethylacrylamide, N,N-dimethylmethacrylamide, N,N-diethylacrylamide, N, N-dimethylmethacrylamide; N-2-hydroxypropyl methacrylamide, or a combination thereof,
b) a polyol, wherein the weight ratio of the water-soluble polymer to the polyol is 0.318:1 to 4:1, and
c) water or a buffer, wherein the RIM solution has a refractive index of 1.36 or greater.