US 11,988,583 B2
Measurement of a dynamic system
Samuel Walker Inman, Atlanta, GA (US); Richard Allen Bryan, Atlanta, GA (US); Nicholas Quan, Richmond Hill, GA (US); and Daniel Bauen, Stone Mountain, GA (US)
Assigned to Lucid Scientific, Inc., Atlanta, GA (US)
Filed by Lucid Scientific, Inc., Atlanta, GA (US)
Filed on Aug. 30, 2019, as Appl. No. 16/556,929.
Claims priority of provisional application 62/725,787, filed on Aug. 31, 2018.
Prior Publication US 2020/0116600 A1, Apr. 16, 2020
Int. Cl. G01N 1/22 (2006.01); G01N 21/64 (2006.01)
CPC G01N 1/2226 (2013.01) [G01N 21/6428 (2013.01); G01N 21/6452 (2013.01); G01N 2021/6432 (2013.01)] 43 Claims
OG exemplary drawing
 
1. An apparatus for measurement of molecule levels in fluid in a receptacle, the apparatus comprising:
a device configured to be attached as part of a cover over a receptacle having a set of wells for holding a biological sample immersed in fluid, wherein the device comprises:
a plurality of optoelectronic sensors arranged to acquire optical signals from respective probes immersed in the fluid, each optical signal representing a molecule level in fluid at a respective probe;
a set of actuators configurable to adjust a relative position of the device and the receptacle; and
control circuitry configured to control the set of actuators to vary the relative position of the device and the receptacle, and to acquire the optical signals at a plurality of relative positions; and
a lid configured to be attached to the device to form the cover, the lid comprising:
a surface configured to cover the wells of the receptacle; and
a set of probes, such that each probe extends substantially perpendicularly from the surface of the lid;
wherein the lid is configured such that a location of each probe of the lid corresponds to a location of an optoelectronic sensor of the device such that, when the lid is attached to the device, an optical path is formed between a sensor of the probe and a corresponding optoelectronic sensor;
wherein the lid is further configured such that the location of each probe of the lid corresponds to a position within a well of the set of wells of the receptacle;
wherein, when the apparatus is attached as part of the cover over the receptacle, varying the relative position of the device and the receptacle causes variation of depth of the probes in the fluid of the wells; and
wherein the device is configured to rest on top of the lid and be fully supported by the lid and the receptacle.