US 11,987,904 B2
Oligonucleotides and methods for preparing
Shuji Ikeda, London (GB); Shozo Fujita, London (GB); and Tsuyoshi Fujihara, London (GB)
Assigned to APTAMER GROUP LIMITED, York (GB)
Appl. No. 16/081,635
Filed by Aptamer Group Limited, York (GB)
PCT Filed Mar. 2, 2017, PCT No. PCT/EP2017/054963
§ 371(c)(1), (2) Date Aug. 31, 2018,
PCT Pub. No. WO2017/149097, PCT Pub. Date Sep. 8, 2017.
Claims priority of application No. 1603789 (GB), filed on Mar. 4, 2016.
Prior Publication US 2023/0132627 A1, May 4, 2023
Int. Cl. C40B 40/06 (2006.01); C12N 15/10 (2006.01); C12N 15/115 (2010.01); C40B 40/08 (2006.01)
CPC C40B 40/08 (2013.01) [C12N 15/1093 (2013.01); C12N 15/115 (2013.01); C12N 2310/16 (2013.01); C12N 2310/52 (2013.01); C12N 2320/11 (2013.01); C12N 2330/31 (2013.01)] 13 Claims
OG exemplary drawing
 
1. An oligonucleotide construct comprising a functional element and a coding element, wherein the functional element comprises a functional sequence, the functional sequence comprising a sequence of nucleotides in which one or more, or each, nucleotide is modified and the coding element comprises a coding sequence, the coding sequence comprising a sequence of nucleotides which do not contain the modifications of the functional sequence, wherein the coding sequence encodes the sequence structure of the functional sequence and wherein the coding sequence is an oligonucleotide polymer of n-mers, or a plurality of different n-mers, where n is an integer of 2 or greater and each n-mer corresponds to a single nucleotide in the functional sequence and the coding sequence has n times the number of nucleotides as the functional sequence.