	US 11,987,853 B2
	Method for chromatographic purification of viscous loads
Eric Valery, Lyons (FR); and Cédric Prieur, Genas (FR)
Assigned to NOVASEP PROCESS SOLUTIONS, Saint-Maurice-de-Beynost (FR)
Appl. No. 17/047,672
Filed by NOVASEP PROCESS SOLUTIONS, Saint-Maurice-de-Beynost (FR)
PCT Filed Apr. 22, 2019, PCT No. PCT/EP2019/060255 § 371(c)(1), (2) Date Oct. 14, 2020, PCT Pub. No. WO2019/206842, PCT Pub. Date Oct. 31, 2019.
Claims priority of application No. 18305503 (EP), filed on Apr. 23, 2018.
Prior Publication US 2021/0032711 A1, Feb. 4, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C13K 11/00 (2006.01); B01D 15/18 (2006.01); B01D 15/42 (2006.01); C13K 1/00 (2006.01)

CPC C13K 11/00 (2013.01) [B01D 15/185 (2013.01); B01D 15/1871 (2013.01); B01D 15/426 (2013.01); C13K 1/00 (2013.01)]

12 Claims

1. A method for purifying a mixture to be separated, in a multicolumn chromatography system that comprises a plurality of columns and intercolumn fluidic links, the method comprising successively and cyclically:—a step of collecting a raffinate, a step of injecting the mixture to be separated into the multicolumn chromatography system, a step of collecting an extract and a step of injecting eluent into the multicolumn chromatography system, at an operating temperature; wherein the method comprises moving a fluid through the intercolumn fluidic links at a velocity greater than 0.5 m/s; wherein the mixture to be separated has a viscosity at 20° C. greater than or equal to 3 mPa·s; and wherein a dry matter mass concentration of the mixture to be separated is equal, within 5%, to a threshold concentration, said threshold concentration being such that:—a first viscosity of the mixture to be separated, at a second dry matter mass concentration equal to the threshold concentration and at the operating temperature, is equal to twice a second viscosity of the mixture to be separated, at a dry matter mass concentration equal to 85% of the threshold concentration and at the operating temperature.