US 11,987,846 B2
Biomarker pairs for predicting preterm birth
John Jay Boniface, Salt Lake City, UT (US); Andrew Gassman, Salt Lake City, UT (US); Jeff Flick, Salt Lake City, UT (US); Chad Bradford, Salt Lake City, UT (US); Ashoka Polpitiya, Salt Lake City, UT (US); Tracey Cristine Fleischer, Sandy, UT (US); Durlin Edward Hickok, Seattle, WA (US); Paul Kearney, Seattle, WA (US); and Gregory Charles Critchfield, Holladay, UT (US)
Assigned to Sera Prognostics, Inc., Salt Lake City, UT (US)
Filed by Sera Prognostics, Inc., Salt Lake City, UT (US)
Filed on Mar. 1, 2021, as Appl. No. 17/189,048.
Application 17/189,048 is a continuation of application No. 16/380,938, filed on Apr. 10, 2019, granted, now 10,961,584.
Application 16/380,938 is a continuation of application No. 15/186,322, filed on Jun. 17, 2016, granted, now 10,392,665, issued on Aug. 27, 2019.
Claims priority of provisional application 62/290,796, filed on Feb. 3, 2016.
Claims priority of provisional application 62/387,420, filed on Dec. 24, 2015.
Claims priority of provisional application 62/182,349, filed on Jun. 19, 2015.
Prior Publication US 2021/0180135 A1, Jun. 17, 2021
Int. Cl. C12Q 1/6883 (2018.01); C07K 14/47 (2006.01); G01N 33/68 (2006.01)
CPC C12Q 1/6883 (2013.01) [C07K 14/47 (2013.01); G01N 33/689 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/4713 (2013.01); G01N 2333/4745 (2013.01)] 18 Claims
 
1. A method for providing prophylactic treatment of preterm birth in a pregnant human patient, the method comprising:
(i) measuring in a biological sample obtained from said patient a panel of isolated biomarkers comprising IBP4 and SHBG, wherein measuring comprises subjecting the biological sample to a proteomics work-flow comprised of mass spectrometry (MS);
(ii) calculating a risk score using a reversal value for IBP4/SHBG; and
(iii) administering to said patient, where said risk score is above a reference risk score, a treatment regimen comprising a progesterone treatment, cervical cerclage, serial cervical length measurements, or an antenatal corticosteroid.