	US 11,987,835 B2
	Amino acid-sensing diguanylate cyclase and methods of use
Catherine Robinson, Eugene, OR (US); Emily Sweeney, Eugene, OR (US); and Karen Guillemin, Eugene, OR (US)
Assigned to University of Oregon, Eugene, OR (US)
Filed by University of Oregon, Eugene, OR (US)
Filed on Dec. 19, 2022, as Appl. No. 18/067,977.
Application 18/067,977 is a division of application No. 16/923,816, filed on Jul. 8, 2020, granted, now 11,566,272.
Claims priority of provisional application 62/871,547, filed on Jul. 8, 2019.
Prior Publication US 2023/0183775 A1, Jun. 15, 2023
Int. Cl. C12Q 1/48 (2006.01); A61K 35/74 (2015.01); C07K 14/195 (2006.01); C12N 9/12 (2006.01); G01N 33/68 (2006.01)

CPC C12Q 1/485 (2013.01) [A61K 35/74 (2013.01); C07K 14/195 (2013.01); C12N 9/1241 (2013.01); C12Y 207/07065 (2013.01); G01N 33/6806 (2013.01); C07K 2319/60 (2013.01); G01N 2333/9125 (2013.01)]

19 Claims

1. A fusion protein comprising a sensing proline diguanylate cyclase enzyme (SpdE) polypeptide tandem Per-Arnt-Sim/double Cache (PAS/dCache) domain linked to a heterologous signaling domain, a detectable label, or both.