CPC C12N 9/1077 (2013.01) [A61K 38/45 (2013.01); A61K 47/60 (2017.08); C07K 7/64 (2013.01); C12Y 204/02004 (2013.01); C07K 2319/00 (2013.01)] | 18 Claims |
1. A compound having a stricture according to Formula I-A:
CPP-L-TP (I-A),
wherein:
CPP is a cyclic cell-penetrating peptide (cCPP);
TP is thymidine phosphorylase, or an active fragment or analog thereof; and has an amino acid sequence that is at least 95% identical to SEQ ID NO. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, or 13;
L is a linker; and
wherein L is a covalently bound to the side chain of an amino acid on the CPP and to the N-terminus of the TP;
the cCPP has a sequence comprising any of Formula IV-A-D:
![]() wherein:
each of AAH1 and AAH2 are independently a D or L hydrophobic aromatic amino acid;
at each instance and when present, each of AAU and AAZ are independently a D or L amino acid;
m and n are independently selected from a number from 0 to 6; and
wherein Formula IV-A-D comprise at least three consecutive arginine, and at least three-consecutive hydrophobic aromatic amino acids.
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