	US 11,987,818 B2
	Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
Margie Tabuga Borra-Garske, Palo Alto, CA (US); Oscar Alvizo, Fremont, CA (US); Melissa Ann Mayo, Foster City, CA (US); Stephan Jenne, Foster City, CA (US); Auric Anthony Sowell-Kantz, Fairfax, CA (US); and Carmela Molinaro, Colonia, NJ (US)
Assigned to Codexis, Inc., Redwood City, CA (US)
Filed by Codexis, Inc., Redwood City, CA (US)
Filed on May 26, 2021, as Appl. No. 17/330,686.
Application 17/330,686 is a division of application No. 16/319,537, granted, now 11,046,936, previously published as PCT/US2017/045838, filed on Aug. 8, 2017.
Claims priority of provisional application 62/380,165, filed on Aug. 26, 2016.
Prior Publication US 2021/0284973 A1, Sep. 16, 2021
Int. Cl. C12N 9/06 (2006.01); C12N 9/02 (2006.01)

CPC C12N 9/0028 (2013.01) [C12N 9/0036 (2013.01); C12Y 105/01 (2013.01); C12Y 106/00 (2013.01)]

16 Claims

1. An engineered polynucleotide encoding an engineered imine or oxime reductase polypeptide comprising an amino acid sequence with at least 80% sequence identity to a reference sequence of SEQ ID NO: 14, and wherein said engineered polypeptide has imine reductase activity.