	US 11,987,816 B2
	Composition for inducing dedifferentiation from somatic cells to induced pluripotent stem cells and method of inducing dedifferentiation using same
Byoung Soo Kim, Seoul (KR); and Seung Jin Lee, Seoul (KR)
Assigned to Korea University Research and Business Foundation, Seoul (KR)
Appl. No. 17/043,836
Filed by KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, Seoul (KR)
PCT Filed Apr. 2, 2019, PCT No. PCT/KR2019/003898 § 371(c)(1), (2) Date Sep. 30, 2020, PCT Pub. No. WO2019/194549, PCT Pub. Date Oct. 10, 2019.
Claims priority of application No. 10-2018-0038371 (KR), filed on Apr. 2, 2018; and application No. 10-2018-0085476 (KR), filed on Jul. 23, 2018.
Prior Publication US 2021/0403877 A1, Dec. 30, 2021
Int. Cl. C12N 5/074 (2010.01)

CPC C12N 5/0696 (2013.01) [C12N 2501/604 (2013.01); C12N 2501/606 (2013.01); C12N 2501/998 (2013.01); C12N 2502/025 (2013.01); C12N 2506/025 (2013.01); C12N 2506/28 (2013.01); C12N 2533/54 (2013.01)]

4 Claims

1. A method for increasing efficiency of dedifferentiation from a somatic cell to an induced pluripotent stem cell (iPS), the method comprising:

a somatic cell transformation step of increasing the expression of CXCR2 by transfection of CXCR2; and

a somatic cell culturing step of culturing the transformed somatic cell,

wherein the somatic cell is an epithelial cell and

wherein the cell culturing step is performed in placenta-derived cell conditioned medium.