US 11,987,807 B2
Isolated human lung progenitor cells and uses thereof
Jayaraj Rajagopal, Lincoln, MA (US); and Hongmei Mou, Medford, MA (US)
Assigned to The General Hospital Corporation, Boston, MA (US)
Filed by THE GENERAL HOSPITAL CORPORATION, Boston, MA (US)
Filed on Nov. 24, 2021, as Appl. No. 17/534,977.
Application 17/534,977 is a division of application No. 16/368,344, filed on Mar. 28, 2019, granted, now 11,214,769.
Application 16/368,344 is a division of application No. 15/635,975, filed on Jun. 28, 2017, granted, now 10,273,450, issued on Apr. 30, 2019.
Application 15/635,975 is a division of application No. 14/371,627, granted, now 9,828,583, issued on Nov. 28, 2017, previously published as PCT/US2013/021186, filed on Jan. 11, 2013.
Claims priority of provisional application 61/619,568, filed on Apr. 3, 2012.
Claims priority of provisional application 61/586,551, filed on Jan. 13, 2012.
Prior Publication US 2022/0221779 A1, Jul. 14, 2022
Int. Cl. G03B 21/28 (2006.01); A61K 35/42 (2015.01); A61L 27/38 (2006.01); A61L 27/56 (2006.01); A61L 27/58 (2006.01); C12N 5/071 (2010.01); C12N 5/074 (2010.01); G01N 33/68 (2006.01); A61K 9/00 (2006.01)
CPC C12N 5/0607 (2013.01) [A61K 35/42 (2013.01); A61L 27/3834 (2013.01); A61L 27/3882 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); C12N 5/0678 (2013.01); C12N 5/068 (2013.01); C12N 5/0688 (2013.01); C12N 5/0689 (2013.01); G01N 33/6884 (2013.01); G03B 21/28 (2013.01); A61K 9/0073 (2013.01); A61L 2430/22 (2013.01); C12N 2501/115 (2013.01); C12N 2501/117 (2013.01); C12N 2501/15 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/385 (2013.01); C12N 2501/415 (2013.01); C12N 2501/727 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); C12N 2533/90 (2013.01)] 4 Claims
OG exemplary drawing
 
1. A method of making a cell composition for aerosol delivery, the method comprising: contacting an isolated and viable human Nkx2.1 positive, Sox 2 positive proximal airway multipotent progenitor cell with a propellant, wherein the proximal airway multipotent progenitor cell is committed to the lung lineage.