US 11,987,801 B2
Altering tissue tropism of adeno-associated viruses
Luk H. Vandenberghe, Weston, MA (US); Pauline Schmit, Boston, MA (US); Christopher Tipper, Cambridge, MA (US); Carmen Unzu, Boston, MA (US); and Eric Zinn, Lynn, MA (US)
Assigned to Massachusetts Eye and Ear Infirmary, Boston, MA (US); and The Schepens Eye Research Institute, Inc., Boston, MA (US)
Appl. No. 17/053,412
Filed by Massachusetts Eye and Ear Infirmary, Boston, MA (US); and The Schepens Eye Research Institute, Inc., Boston, MA (US)
PCT Filed May 10, 2019, PCT No. PCT/US2019/031851
§ 371(c)(1), (2) Date Nov. 6, 2020,
PCT Pub. No. WO2019/217911, PCT Pub. Date Nov. 14, 2019.
Claims priority of provisional application 62/841,179, filed on Apr. 30, 2019.
Claims priority of provisional application 62/670,543, filed on May 11, 2018.
Prior Publication US 2023/0051611 A1, Feb. 16, 2023
Int. Cl. C12N 15/86 (2006.01); C07K 14/005 (2006.01); C12N 15/10 (2006.01)
CPC C12N 15/86 (2013.01) [C07K 14/005 (2013.01); C12N 15/102 (2013.01); C12N 2750/14143 (2013.01)] 15 Claims
 
1. An adeno-associated virus (AAV) capsid protein comprising the amino acid sequence selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, and SEQ ID NO: 17.