US 11,987,795 B2
Methods of modulating SLC7A11 pre-mRNA transcripts for diseases and conditions associated with expression of SLC7A11
Vamsi Krishna Mootha, Cambridge, MA (US); and Alexis André Jourdain, Cambridge, MA (US)
Assigned to The Broad Institute, Inc., Cambridge, MA (US); and The General Hospital Corporation, Boston, MA (US)
Filed by The Broad Institute, Inc., Cambridge, MA (US); and The General Hospital Corporation, Boston, MA (US)
Filed on Sep. 22, 2021, as Appl. No. 17/482,292.
Claims priority of provisional application 63/117,830, filed on Nov. 24, 2020.
Prior Publication US 2022/0162617 A1, May 26, 2022
Int. Cl. C07H 21/04 (2006.01); A61K 31/7088 (2006.01); C12N 15/113 (2010.01)
CPC C12N 15/1138 (2013.01) [A61K 31/7088 (2013.01)] 12 Claims
 
1. A method for inducing exon skipping in a cell during splicing of human SLC7A11 pre-mRNA to form SLC7A11 mRNA lacking exon 7, the method comprising contacting the SLC7A11 pre-mRNA comprising exons 1-12 in the cell with an antisense oligonucleotide, wherein the antisense oligonucleotide comprises the nucleotide sequence set forth in any of SEQ ID NO:1-11.