US 11,987,788 B2
Methods and compositions for changing the composition of the skin microbiome using complex mixtures of bacterial strains
Bernhard Pätzold, Berchem (BE); and Marc Güell, Barcelona (ES)
Assigned to S-Biomedic NV, Beerse (BE)
Filed by S-Biomedic NV, Beerse (BE)
Filed on Aug. 28, 2020, as Appl. No. 17/006,054.
Application 17/006,054 is a continuation of application No. 15/567,941, granted, now 10,774,305, previously published as PCT/US2016/028421, filed on Apr. 20, 2016.
Claims priority of provisional application 62/216,258, filed on Sep. 9, 2015.
Claims priority of provisional application 62/150,225, filed on Apr. 20, 2015.
Prior Publication US 2020/0392452 A1, Dec. 17, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 1/20 (2006.01); A61K 9/00 (2006.01); A61K 35/00 (2006.01); A61K 35/74 (2015.01); A61P 17/10 (2006.01); C12Q 1/04 (2006.01); C12Q 1/533 (2006.01); C12R 1/01 (2006.01)
CPC C12N 1/20 (2013.01) [A61K 9/0014 (2013.01); A61K 35/74 (2013.01); A61P 17/10 (2018.01); C12N 1/205 (2021.05); C12Q 1/04 (2013.01); C12Q 1/533 (2013.01); A61K 2035/115 (2013.01); C12R 2001/01 (2021.05); G01N 2333/195 (2013.01)] 12 Claims
 
1. A method for treating acne, comprising:
topically administering a disinfectant or antibiotic to skin of a subject with acne; and
topically administering a composition comprising one or more live bacterial strains to the skin of the subject following administration of the disinfectant or antibiotic, wherein the one or more live bacterial strains are Propionibacterium acnes (P. acnes) bacterial strains that comprise a sequence selected from any one of SEQ ID NOs: 5, 25, 44 and 58.